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KMID : 0043319970200040346
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Archives of Pharmacal Research
1997 Volume.20 No. 4 p.346 ~ p.350
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Synthesis and Activity of a Potent -glucosidase inhibitor, (1R, 6R, 8S)-cis-1,6-dihydroxypyrrolizidine, and its isomer
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Jung Kyeong-Eun
Kang Yong-Koo
Kim Dong-Jin
Park Sang-Woo
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Abstract
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The synthesis of cis- and trans-1,6-dihydroxypyrrolizidine starting from trans-4-hydroxy-L-proline and their evaluation as glycosidase inhibitors are reported. The cis-isomer was found to be a potent inhibitor against .alpha.-glucosidase and showed weak inhibitory effect against other glycosidases. The trans-isomer exhibited weak inhibitions of b-glucosidase and amylo-glucosidase and poor inhibition of other glycosidases.
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KEYWORD
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a-glucosidase inhibitor, swainsonine, pyrrolizidine derivatives
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